RAPROS--The first medicine for CKD cats in the world

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softvoice2007
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Lid geworden op: 24 jan 2019 16:32

RAPROS--The first medicine for CKD cats in the world

Bericht door softvoice2007 » 08 feb 2019 16:22

Have you heard about it?Japan has already developed the medicine to heal CKD cats, which is called rapros.

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https://www.toray.com/products/chemicals/che_0070.html

here is also the link of Description but in Japanese https://www.toray.jp/chemical/animal/pdf/rapros.pdf

and moreover hardly can find more information in English for this medicine(unless you can read Japanese or Chinese),

some of my taiwanese friends who got this medicine through local japanese vet when they visit Japan.

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Rik
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Re: RAPROS--The first medicine for CKD cats in the world

Bericht door Rik » 08 feb 2019 16:36

Rapros (Beraprost)

Rapros (beraprost sodium) is a drug in the prostacyclin (PGI2) family made by Toray Industries in Japan.

Beraprost belongs to the prostanoid family of drugs. These medications are vasodilators, i.e. they relax the blood vessels. Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium (2007) Mitchell JA, Ali F, Bailey L, Moreno L & Harrington LS Experimental Physiology 93(1) pp141–147 says "Nitric oxide and prostacyclin are arguably the most important cardioprotective hormones yet described." This class of medication is commonly used in humans to treat pulmonary arterial hypertension, though beraprost is not the most effective drug for that purpose.

It is not uncommon to use heart medications for patients with CKD (see ACE inhibitors and ARBs above). Beraprost sodium improves survival rates in anti-glomerular basement mmbrane glomerulonephritis and 56 nephrectomized chronic kidney disease in rats (2013) Yamaguchi S, Inada C, Tamura M, Sato N, Yamada M, Itaba S, Okazaki S, Matsuura H, Fujii S, Matsuda F, Goto Y, Mochizuki H, Kurumatani H, Miyamoto M European Journal of Pharmacology 714 pp325-331 reports on trials of the medication in rats with kidney problems.

Toray Industries also produce a human medicine containing beraprost, which is licensed in Japan and other countries. Orally active prostacyclin analogue beraprost sodium in patients with chronic kidney disease: a randomized, double-blind, placebo-controlled, phase II dose finding trial(2015) Koyama A, Fujita T, Gejyo F, Origasa H, Isono M, Kurumatani H, Okada K, Kanoh H, Kiriyama T & Yamada S BMC Nephrology 16 pp165 reports on a short trial in humans which was trying to find the correct dose for kidney disease patients.

Nikkei Asian Review reports that beraprost was approved in Japan for the treatment of CKD in cats with effect from April 2017. A double-blind placebo-controlled multicenter prospective randomized study of beraprost sodium treatment for cats with chronic kidney disease (2018) Takenaka M, Iio A, Sato R, Sakamoto T & Kurumatani H Journal of Veterinary Internal Medicine 32(1) pp236-248 looked at the use of beraprost in CKD cats in 22 veterinary practices in Japan. The cats in the study had a USG below 1.035, creatinine over 1.6mg/dl (140 mmol/l) and a UPC ratio below 1.5. After six months creatinine and the phosphorus:calcium ratio increased in the placebo cats but not in the cats receiving beraprost. The study found that beraprost appears to be safe but "there was was no significant change in the USG in either group."

The manufacturer of Rapros claims it may slow the progression of CKD. At present the jury is out on whether ACE inhibitors and ARBs can do this and I think the same probably applies to Rapros.

I am not aware of any plans to launch Rapros outside the Japanese market.
https://www.felinecrf.org/proteinuria.htm#rapros

A Double-blind, Placebo-controlled, Multicenter, Prospective, Randomized Study of Beraprost Sodium Treatment for Cats with Chronic Kidney Disease.
https://www.ncbi.nlm.nih.gov/pubmed/29131397

There is much more to be found under the name Beraprost.
Grtz, Rik
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ErikPhilippus
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Re: RAPROS--The first medicine for CKD cats in the world

Bericht door ErikPhilippus » 08 feb 2019 17:50

Interessant.... Maar in de case study zie ik dat er sprake is van katten met een wel hele lichte vorm van nierfalen, gezien de waardes voor USG, Creatinine en UPC ratio..... Vraag me af wat het effect is bij katten met serieus nierfalen...

Ik vind de claim dat het katten met nierfalen kan genezen, daarom ook wel wat voorbarig. Ik begrijp uit jouw stuk dat het de progressie van de ziekte remt - en dat is iets anders dan genezen.

Bedankt voor het delen, Rik!
Ga me er in verdiepen.

Goed weekend,
Erik
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Re: RAPROS--The first medicine for CKD cats in the world

Bericht door Rik » 08 feb 2019 17:55

ErikPhilippus schreef:
08 feb 2019 17:50
Bedankt voor het delen, Rik!
Oorspronkelijk bericht (en deling) natuurlijk van softvoice2007 :)

Ik heb het ook nog niet zo bestudeerd maar had even wat linkjes opgezocht naar aanleiding van het openingsbericht. Onder de naam beraprost sodium kon in ieder geval veel meer gevonden worden.

Bij het woord genezen van nierfalen gaan bij mij alle alarmbelletjes af :)
Grtz, Rik
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Re: RAPROS--The first medicine for CKD cats in the world

Bericht door ErikPhilippus » 08 feb 2019 19:07

Of course - thanx Softvoice 2007!
Any additional info is of course welcome!
Afbeelding Dalí (2001-2017) + Gaudí (2001) + Lumi (2014) + Amber (2016) + Oscar (2016)
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